The Three Waves of Biological Ageing – Proteome Changes in the Blood 34 Years 60 Years 78 Years 0 500 1,000 1,500 Significant Proteins 20 30 40 50 60 70 80+ Age (Years) The Three Waves of Biological Ageing Changes in the Blood Proteome (Plasma Profile) Across the Lifespan p < 0,05 p < 0,01 p < 0,001 p < 0,0001 Significance Levels Source: Lehallier et al., Nature Medicine, 2019 — n = 4,263 participants, aged 18–95