Psychoneuroimmunology (PNI)
The triangle between mind, nervous system & immune system — tap a node
PNI Triangle — Mind, Nervous System and Immune System Neuropeptides · Cortisol Cytokines · Interleukins Signal Molecules · Oxytocin PNI Regulation & Counter-regulation 🧠 Mind ⚡ Nervous System 🛡️ Immune System Placebo Effect Nocebo Effect Optimism Cortisol Axis Sleep & Circadian Stress Response NK Cells ↑ Exercise Oxytocin Hugs Autoimmune Regulation
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🧠 Mind — The Immune Regulator
The mind influences the immune system directly via the nervous system. The placebo effect achieves measurable healing rates of up to 50% — not because of imagination, but because suggestion triggers real neuroimmunological changes. The nocebo effect shows the flip side: negative beliefs can seriously damage the body. "Laughter is the best medicine" — scientifically proven.
Placebo Effect Nocebo Effect Autosuggestion Optimism
⚡ Nervous System — Control Centre
The nervous system translates mental states into physical responses — via neuropeptides, the cortisol axis and the autonomic nervous system. Chronic stress leads to dysregulation: elevated cortisol suppresses immune cells. Just 2 nights of sleep deprivation impair immune functions that do not fully normalise even after 3 nights of normal sleep.
HPA Axis Cortisol Sleep Circadian Rhythm
🛡️ Immune System — Complex & Regulated
A "strong" immune system doesn't mean maximally active — it means correctly regulated. NK cells rise after acute exercise. Oxytocin (triggered by social closeness & hugs) measurably improves immune function. Autoimmune diseases often arise from overactivity in the wrong area — not from too little activity.
NK Cells Oxytocin Cytokines Autoimmune Regulation